CMX-020 can be delivered intravenously in a hospital setting and orally


Cmxtwenty is a Milwaukee-based pharmaceutical company focused on development of a non-narcotic treatment for pain using a unique lipid molecule called CMX-020. This molecule is an analog of arachidonic acid with a multi-modal mechanism of action, including CB1, CB2, Melatonin MT1, Adenosine A3, kappa- and delta-opioid, and TRPV1 receptors. Unlike opioid pain therapeutics, CMX-020 does not activate the mu-opioid receptor that produces devastating effects. CMX-020’s physiochemical properties are similar to the active metabolite of acetaminophen (AM404). Like acetaminophen, CMX-020 reduces pain without feeling the effects of the drug itself. The lack of “drug feel” associated with CMX-020 mitigates side effect complications and the risk of addiction to the patient. CMX-020 can be delivered intravenously in a hospital setting and orally. Cmxtwenty maintains international patent filings on CMX-020 through 2029 (excluding extensions).


The CMX-020 chemistry was initially developed in 2007 around research at the Medical College of Wisconsin. Our research demonstrated that the analgesic properties of 14,15-EET found endogenously in the periaqueductal grey area (PAG) of the brain (the primary control center for descending pain modulation) performed like morphine in the rat tail-flick assay and activated the expression of beta-endorphin and met-enkephalin. (Terashvili et al, 2008). CMX-020 was designed to mimic the pharmacology of the 14,15-EET. The company has been funded by angel investors.


Lane Brostrom, PhD, MBA

Chairman and CEO

Lane manages personnel, strategy, science, finance, administration, intellectual property, and daily operations for Cmxtwenty. As Managing Director of TechStar from 2001-2006, he facilitated the launch of 12 biomedical companies originating from university research.

David Stowe, MD, PhD

Board Member

Dr. Stowe is a practicing anesthesiologist and Professor of Anesthesiology and Physiology at the Medical College of Wisconsin. Dr. Stowe has served as scientific advisor, medical monitor, and clinical advisor to the Cmxtwenty since 2008.

Frank Castellana, MD, Eng. ScD

Board Member

Dr. Castellana is a former Vice President of World Wide Medicines Group for Bristol-Myers Squibb and assisted in the acquisitions of new drug candidates. Dr. Castellana is a key authority in clinical development strategies: market analysis, target product profile (TPP), and valuation.

J.R. (Camille) Falck, PhD

Board Member

Dr. Falck was instrumental in discovery of the CMX-020 chemistry. Camille is actively involved in the CMX-020 synthesis development and manufacturing. Dr. Falck is Distinguished Chair in Chemistry and Professor of Pharmacology at the University of Texas Southwestern.

John Luellwitz, BBA

Board Member

John assists with managing Board activities and oversees key financial relationships, including shareholders and Cmxtwenty’s Australian subsidiary. Mr. Luellwitz is a former Director of Business Development with Ernst & Young in Milwaukee, Wisconsin.

Eckhart Grohmann, PhD

Board Member

Dr. Grohmann is the former chairman and president of Milwaukee’s Aluminum Casting & Engineering Co., a firm he acquired in 1965 and sold in 2007. He earned a Diplom Kaufmann (MBA) from the University of Mannheim and an honorary Doctor of Engineering degree from MSOE.

David Harder, PhD

Board Member

Dr. Harder is Professor of Physiology, Associate Dean of Research and Acting Director of the Cardiovascular Research Center at the Medical College of Wisconsin. Dr. Harder is in the top five percent of funded investigators by NIH over the past 25 years.

Dennis Torkko, BBA, CPA

Vice President

Dennis was a partner at Arthur Andersen for 22 years in Milwaukee and Chicago and continues as a serial entrepreneur specializing in the healthcare sector. He has extensive experience with the FDA and FCC, media and communications, and finance.

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